H2N2V1, France, Analysis, bibRecord, 000211

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

Identifieur interne : 000211 ( France/Analysis ); précédent : 000210; suivant : 000212

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

Auteurs : Thierry Boge [France] ; Michel Rémigy [France] ; Sarah Vaudaine [France] ; Jérôme Tanguy [France] ; Raphaëlle Bourdet-Sicard [France] ; Sylvie Van Der Werf [France]

Source :

Vaccine [ 0264-410X ] ; 2009-09-18.

RBID : Hal:pasteur-00457701

Abstract

BACKGROUND: Influenza vaccination is recommended for the elderly in many countries, but immune responses are weaker compared to younger adults. OBJECTIVE: To investigate the impact of daily consumption of a probiotic dairy drink on the immune response to influenza vaccination in an elderly population of healthy volunteers over 70 years of age. DESIGN: Two randomised, multicentre, double-blind, controlled studies were conducted during two vaccination seasons in 2005-2006 (pilot) and 2006-2007 (confirmatory). Eighty-six and 222 elderly volunteers consumed either a fermented dairy drink, containing the probiotic strain Lactobacillus casei DN-114 001 and yoghurt ferments (Actimel, or a non-fermented control dairy product twice daily for a period of 7 weeks (pilot) or 13 weeks (confirmatory). Vaccination occurred after 4 weeks of product consumption. Geometric mean antibody titres (GMT) against the 3 viral strains composing the vaccine (H1N1, H3N2, and B) were measured at several time intervals post-vaccination by haemagglutination inhibition test. RESULTS: In the pilot study, the influenza-specific antibody titres increased after vaccination, being consistently higher in the probiotic product group compared to the control group under product consumption. Similarly, in the confirmatory study, titres against the B strain increased significantly more in the probiotic group than in the control group at 3, 6 and 9 weeks post-vaccination under product consumption (p=0.020). Significant differences in seroconversion between the groups by intended to treat analysis were still found 5 months after vaccination. Similar GMT results were observed for the H3N2 strain and H1N1 strain, confirming the results of the pilot study. CONCLUSION: These studies demonstrate that daily consumption of this particular probiotic product increased relevant specific antibody responses to influenza vaccination in individuals of over 70 years of age and may therefore provide a health benefit in this population.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-00457701

DOI: 10.1016/j.vaccine.2009.06.094

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000010
to stream Hal, to step Curation: 000010
to stream Hal, to step Checkpoint: 000285
to stream Main, to step Merge: 001009
to stream Main, to step Curation: 001001
to stream Main, to step Exploration: 001001
to stream France, to step Extraction: 000211

Links to Exploration step

Hal:pasteur-00457701

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>BACKGROUND: Influenza vaccination is recommended for the elderly in many countries, but immune responses are weaker compared to younger adults. OBJECTIVE: To investigate the impact of daily consumption of a probiotic dairy drink on the immune response to influenza vaccination in an elderly population of healthy volunteers over 70 years of age. DESIGN: Two randomised, multicentre, double-blind, controlled studies were conducted during two vaccination seasons in 2005-2006 (pilot) and 2006-2007 (confirmatory). Eighty-six and 222 elderly volunteers consumed either a fermented dairy drink, containing the probiotic strain Lactobacillus casei DN-114 001 and yoghurt ferments (Actimel, or a non-fermented control dairy product twice daily for a period of 7 weeks (pilot) or 13 weeks (confirmatory). Vaccination occurred after 4 weeks of product consumption. Geometric mean antibody titres (GMT) against the 3 viral strains composing the vaccine (H1N1, H3N2, and B) were measured at several time intervals post-vaccination by haemagglutination inhibition test. RESULTS: In the pilot study, the influenza-specific antibody titres increased after vaccination, being consistently higher in the probiotic product group compared to the control group under product consumption. Similarly, in the confirmatory study, titres against the B strain increased significantly more in the probiotic group than in the control group at 3, 6 and 9 weeks post-vaccination under product consumption (p=0.020). Significant differences in seroconversion between the groups by intended to treat analysis were still found 5 months after vaccination. Similar GMT results were observed for the H3N2 strain and H1N1 strain, confirming the results of the pilot study. CONCLUSION: These studies demonstrate that daily consumption of this particular probiotic product increased relevant specific antibody responses to influenza vaccination in individuals of over 70 years of age and may therefore provide a health benefit in this population.</p>
            </div>
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<tree><country name="France"><noRegion><name sortKey="Boge, Thierry" sort="Boge, Thierry" uniqKey="Boge T" first="Thierry" last="Boge">Thierry Boge</name>
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<name sortKey="Bourdet Sicard, Raphaelle" sort="Bourdet Sicard, Raphaelle" uniqKey="Bourdet Sicard R" first="Raphaëlle" last="Bourdet-Sicard">Raphaëlle Bourdet-Sicard</name>
<name sortKey="Remigy, Michel" sort="Remigy, Michel" uniqKey="Remigy M" first="Michel" last="Rémigy">Michel Rémigy</name>
<name sortKey="Tanguy, Jerome" sort="Tanguy, Jerome" uniqKey="Tanguy J" first="Jérôme" last="Tanguy">Jérôme Tanguy</name>
<name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<name sortKey="Vaudaine, Sarah" sort="Vaudaine, Sarah" uniqKey="Vaudaine S" first="Sarah" last="Vaudaine">Sarah Vaudaine</name>
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</record>

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   |texte=   A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.
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A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

Source :

Abstract

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Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri